Marysville, PA is a picturesque town located in the southern tip of Perry County. The 2 1/2 miles square borough is bounded by mountains to the north and the south, by the Susquehanna River to the east, and by Rye Township to the west. US Routes 11 & 15 serve as the primary transportation corridor for Marysville residents.

The Borough was settled in 1755, incorporated as the Borough of Haley in 1866, and then incorporated as the Borough of Marysville in 1867.